Researchers have discovered a novel technique that dramatically improves the cryotolerance and developmental ability of rat fertilized oocytes (eggs). This breakthrough could revolutionize the management of rat colonies and reduce the number of animals needed for genetic research. By comparing in vivo (natural mating) and in vitro (laboratory-produced) fertilized oocytes, the team found that those produced naturally had higher survival rates and better developmental potential after vitrification (ultra-rapid freezing) and warming. This paves the way for efficient cryopreservation and transportation of rat resources with homozygous genetic mutations, reducing the need for breeding and improving animal welfare. The study’s findings highlight the importance of natural processes in cryopreservation and open new possibilities for advancing genetic engineering and reproductive biology research.
The Quest for Efficient Rat Cryopreservation
Rats are invaluable animal models for understanding human biology and diseases, thanks to their similarity to humans and the availability of powerful engineering’>genetic engineering research and the development of novel therapies. Moreover, the insights gained into the strain-specific differences in cryotolerance and developmental ability underscore the importance of understanding the nuances of natural biological processes in cryopreservation efforts.
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