A new study reveals how wearing medical masks can impact the skin barrier function and microbiome composition in individuals with sensitive skin. The research highlights the importance of proactive skincare strategies, such as applying a moisturizer before mask-wearing, to mitigate the adverse effects and aid in skin barrier repair. This insight is particularly relevant in the post-COVID-19 era, where mask-wearing has become ubiquitous. Skin barrier and skin microbiome play crucial roles in maintaining healthy skin, and understanding their response to mask-wearing is crucial for individuals with sensitive skin.

Mask-Induced Skin Distress
As we navigate a post-COVID-19 world, mask-wearing has become a ubiquitous practice for disease prevention. However, for individuals with sensitive skin, this necessary measure can pose an additional burden. Sensitive skin (SS), characterized by heightened reactivity to environmental stimuli, often leads to discomfort and barrier dysfunction.
The study, conducted by researchers from the Peking University First Hospital, aimed to evaluate the impact of mask-wearing on the skin microbiome and barrier function in women with sensitive skin. The researchers found that just three hours of mask-wearing significantly weakened the skin barrier, as evidenced by increased transepidermal water loss (TEWL), erythema index (EI), and stratum corneum hydration (SCH). Notably, these effects were observed not only in the masked areas but also in the adjacent unmasked areas, suggesting the widespread impact of mask-wearing on skin health.
Mask-Induced Microbiome Disruption
The study also revealed that mask-wearing led to a significant decrease in bacterial diversity on the facial skin of individuals with sensitive skin. This change in the skin microbiome composition was marked by an increase in the abundance of Cutibacterium and decreases in Streptococcus, Prevotella, and Enterobacter. These shifts in the relative abundance of certain bacteria suggest that the mask microenvironment can disrupt the delicate balance of the skin’s microbial community, potentially exacerbating skin issues in individuals with sensitive skin.
Moisturizer: A Barrier to Mask-Related Discomforts
Importantly, the study found that applying a moisturizer containing biological lipids and probiotics before mask-wearing can help mitigate the adverse effects. The moisturizer-treated side showed reduced TEWL and erythema after mask-wearing, as well as faster barrier recovery. This suggests that preemptive skincare can enhance the skin’s resilience and reduce mask-related sensitivity.
The researchers hypothesize that the moisturizer’s formulation, which includes ingredients like squalene, shea butter, and probiotic Vitreoscilla filiformis extracts, effectively strengthens the skin barrier and modulates the skin microbiome, contributing to a more favorable environment for recovery.
Implications and Future Directions
These findings highlight the significant impact of mask-wearing on the skin physiology and microbiome of individuals with sensitive skin. The study emphasizes the importance of proactive skincare strategies, such as applying a barrier-repairing moisturizer before mask-wearing, to mitigate the adverse effects and aid in skin barrier repair.
While this study provides valuable insights, the researchers acknowledge the need for larger-scale and long-term studies to further explore the real-world effects of mask-wearing and comprehensive interventions to protect skin health. As mask-wearing becomes the new normal, understanding and addressing the specific needs of individuals with sensitive skin will be crucial for maintaining optimal skin health and quality of life.
Author credit: This article is based on research by Shaomin Zhong, Yanyun Lai, Jun Na, Yan Wu.
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