Researchers in China have found a groundbreaking way to transform giant panda skin cells into stem cells, paving the way for new conservation efforts to ensure the survival of this iconic species.
Reprogramming Panda Cells
A group of biologists in China have achieved a significant advancein stem cell research. Using common methods for iPSC reprogramming of giant panda skin cells, they were able to successfully generate iPSCs.
The process entails adding a certain microRNA cluster to panda skin cells — called fibroblasts. This instructs the fibroblasts to become what are called iPSCs (induced pluripotent stem cells) — unfated cells that can be directed into turning on any gene that tells them to do anything.
Going back to 2019, the researchers aimed to produce iPSCs that can be developed into male and female germ cells. This bodes well for the survival of the endangered species and could revolutionize giant panda conservation.
Different Strategy for Each Species
In recent years, stem cell biologists have been honing a recipe for transforming fibroblasts into iPSCs. This is vital for regenerative medicine research, since these cells can be coaxed to grow into all types of cells—including those the body used when developing organs and eggs.
Yet surprisingly, the researchers have found that this transformation of fibroblasts to iPSCs varies between species. This thus necessitates introduction of a fresh method for the production of iPSCs in each new animal. Here, the team has refined that process for the giant panda.
This is not the first time that scientists have used iPSCs to aid in wildlife preservation efforts. In recent years, however, conservationists have tapped the power of this technology to potentially help save species such as the zebra, Tasmanian devil and northern white rhino.
Conclusion
The research done by the Chinese scientists has provided new avenues for revival of giant panda. The advance allows scientists to derive stem cells that could be used in conservation efforts to save the endangered and iconic species. Using iPSCs that serve as the precursors of reproductive cells is a key development in conservation efforts for endangered species. This study thus offers hope for the conservation of giant pandas, as well as a variety of endangered species.
