Recent research has revealed a concerning trend – rates of babesiosis, a tick-borne parasitic disease, have been increasing by an average of 9% per year in the United States since 2015. The study also found that 4 in 10 patients with babesiosis were co-infected with other tick-borne illnesses such as Lyme disease. This highlights the need for heightened vigilance among healthcare providers and the importance of preventive measures to combat the spread of these potentially deadly diseases.

The Alarming Rise of Babesiosis and Co-Infections
The study, led by researchers at Penn State Health Milton S. Hershey Medical Center and Penn State College of Medicine, analyzed data from over 250 million individuals in the TriNetX database. They found that the incidence of babesiosis, a tick-borne parasitic disease also known as “American malaria,” has been increasing at a rate of 9% per year between 2015 and 2022.
What’s even more concerning is the high rate of co-infections. The researchers discovered that 42% of those diagnosed with babesiosis were also infected with one or more additional tick-borne diseases, such as Lyme disease, anaplasmosis, and ehrlichiosis. This co-infection rate is significantly higher than what had been found in previous studies, underscoring the need for healthcare providers to be vigilant in screening and treating patients for multiple tick-borne illnesses simultaneously.
Understanding the Impact of Co-Infections and Treatment Implications
Surprisingly, the study found that the presence of co-infections did not appear to worsen the mortality risk for patients with babesiosis. In fact, the researchers observed that the babesiosis-only group had a higher mortality risk compared to the co-infection group.
One possible explanation for this finding is that the concurrent presence of other tick-borne infections may “boost” the immune response, helping the body more effectively fight the babesia parasite. Additionally, the researchers noted that the co-infection group was more likely to be prescribed doxycycline, the first-line antibiotic treatment for Lyme disease, anaplasmosis, and ehrlichiosis. This raises the intriguing question of whether doxycycline could also be an effective treatment for babesiosis, in addition to the standard combination of azithromycin and atovaquone.
More research is needed to fully understand the complex interplay between co-infections and their impact on treatment outcomes. However, this study suggests that a comprehensive approach to managing tick-borne diseases, including screening for multiple infections and potentially exploring alternative treatment options, may be crucial for improving patient outcomes.
Combating the Spread of Tick-Borne Diseases through Prevention and Awareness
The researchers attribute the rising prevalence of babesiosis and other tick-borne diseases to the impacts of climate change, which have influenced the population and distribution of ticks and their animal hosts, such as deer. As a result, ticks may now be present in a wider geographic area, increasing the risk of exposure for people living in or visiting affected regions.
To combat the spread of these diseases, the researchers emphasize the importance of preventive measures. They recommend that individuals living in or visiting areas where babesiosis is endemic, primarily in the Northeastern and Midwestern states, take precautions during the summer months. This includes wearing long-sleeved clothing, using tick repellent, and thoroughly checking for ticks after spending time outdoors.
Additionally, the study highlights the need for increased awareness and vigilance among healthcare providers. By recognizing the potential for co-infections and considering alternative treatment approaches, such as the use of doxycycline, clinicians can better diagnose and manage these complex tick-borne diseases, ultimately improving patient outcomes and reducing the burden of these emerging health threats.