Discover how the revolutionary CREME virtual laboratory is empowering scientists to simulate gene activity and unlock new frontiers in drug discovery, without the limitations of traditional lab work.
Creating New Landscapes of Genetics
In this world, scientists can query millions of genetic mutations, discover druggable targets with promise for a therapeutic pathway, and understand the intricate rules governing gene regulation — all at the flick of a switch.
That view of life is what CREME, a new artificial intelligence system created by researchers at Cold Spring Harbor Laboratory, has now brought into reality. This not only potentially replaces some of the most labor intensive and time-consuming constraints with estimates based on some structure, but also opens up the prospect of geneticists being able to run thousands of virtual experiments on a new gene targeting behaviours without access to huge amounts of experimental biology resources.
Utilizing the potency of CRISPR interference (CRISPRi) technology, CREME permits investigators to ‘knock down’ activity for specific genes virtually and watch how this influences gene expression. This approach can save researchers time and also give them new possibilities for discovery that simply were not true before.
Genome Prediction Unlocking Their Secrets
At the heart of Koo and his team’s research is a focus on learning more about how powerful genome analysis tools driven by AI like Enformer, operate. These models have proven very good at predicting gene expression from DNA sequences, but it has remained elusive as to why they work so well.
The scientists identified a set of genetic rules that Enformer had learned in analysing the genome by using CREME. This discovery potentially paves the way for much faster drug development efforts.
The more you know about how genes are controlled, at a basic level – gene regulation in itself — the more levers of control you will have to fine-tune expression levels up or down as desired,” said Koo. CREME ‘may soon pave the way for geneticists to hunt down new treatment routes after more refinement.
In addition to this, the availability of CREME might allow such researchers an opportunity to make great advances in the field of genetics. Consequently, a more democratic approach to genetic exploration has the capacity to fundamentally transform the field and catalyze greater innovation at an unheard of rate.
Conclusion
From there on, the innovation of CREME an AI-enabled virtual lab took the realm of genetic research to a whole another level. By simulating activity changes from individual genes of interest and learning the rules that dictate the genome for predictive models, this technology has tremendous potential. We believe IXpressGenes can dramatically change how pharmaceutical industries approach drug discovery and enable SGD to leverage the power of a full human genome. CREME can speed up scientific discovery, making new treatments for serious diseases possible sooner by enabling researchers to carry out massive virtual experiments and extract information that may never have been discovered before.
